The dopamine D3 receptor antagonist, SR 21502, facilitates extinction of cocaine conditioned place preference

The dopamine D3 receptor antagonist, SR 21502, facilitates extinction of cocaine conditioned place preference

Highlights • DA D3 receptor antagonism facilitates extinction of cocaine place preference. • DA D3 receptor antagonism fails to establish a conditioned place aversion. • SR 21502 may have potential as an anti-cocaine addiction treatment.

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Bibliographische Detailangaben
Veröffentlicht in:Drug and alcohol dependence 2016-02, Vol.159, p.263-266
Hauptverfasser: Galaj, E, Haynes, J, Nisanov, R, Ananthan, S, Ranaldi, R
Format: Artikel
Sprache:eng
Schlagworte:
Addiction
Animals
Cocaine
Cocaine - pharmacology
Conditioned place preference
Conditioning, Psychological - drug effects
Cues
D3 receptor antagonist
Extinction
Extinction, Psychological - drug effects
Imidazoles - pharmacology
Male
Psychiatry
Pyridines - pharmacology
Rats
Receptors, Dopamine D3 - antagonists & inhibitors
Reward
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Beschreibung
Zusammenfassung:Highlights • DA D3 receptor antagonism facilitates extinction of cocaine place preference. • DA D3 receptor antagonism fails to establish a conditioned place aversion. • SR 21502 may have potential as an anti-cocaine addiction treatment.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2015.11.030