Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

ABSTRACT Epithelial‐mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene varia...

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Veröffentlicht in:	Genetic epidemiology 2015-12, Vol.39 (8), p.689-697
Hauptverfasser:	Lin, Hui-Yi, Tyrer, Jonathan P., Lawrenson, Kate, Dennis, Joe, Anton-Culver, Hoda, Bean, Yukie T., Bisogna, Maria, Brinton, Louise A., Brooks-Wilson, Angela, Carty, Karen, Chen, Zhihua, Chen, Y. Ann, Cook, Linda S., Cramer, Daniel W., Cunningham, Julie M., Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Doherty, Jennifer A., Dörk, Thilo, Easton, Douglas F., Eccles, Diana M., Fasching, Peter A., Fridley, Brooke L., Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G., Glasspool, Rosalind, Gronwald, Jacek, Harter, Philipp, Hasmad, Hanis N., Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle A. T., Hogdall, Claus K., Hogdall, Estrid, Iversen, Edwin S., Jakubowska, Anna, Ji, Bu-Tian, Karlan, Beth Y., Jim, Heather, Kiemeney, Lambertus A., Kjaer, Susanne K., Le, Nhu D., Lee, Alice W., Lester, Jenny, Levine, Douglas A., Liang, Dong, Lim, Boon Kiong, Lissowska, Jolanta, Lubinski, Jan, Lundvall, Lene, Matsuo, Keitaro, McGuire, Valerie, Menon, Usha, Milne, Roger L., Modugno, Francesmary, Moysich, Kirsten B., Nevanlinna, Heli, Eilber, Ursula, Olson, Sara H., Orlow, Irene, Orsulic, Sandra, Pearce, Celeste L., Pejovic, Tanja, Permuth-Wey, Jennifer, Pike, Malcolm C., Poole, Elizabeth M., Risch, Harvey A., Rosen, Barry, Rudolph, Anja, Runnebaum, Ingo B., Rzepecka, Iwona K., Salvesen, Helga B., Schwaab, Ira, Shu, Xiao-Ou, Shvetsov, Yurii B., Song, Honglin, Southey, Melissa C., Spiewankiewicz, Beata, Terry, Kathryn L., Thompson, Pamela J., Tangen, Ingvild L., Tworoger, Shelley S., Vergote, Ignace, Wang-Gohrke, Shan, Wicklund, Kristine G., Wu, Anna H., Wu, Xifeng, Woo, Yin-Ling, Yang, Hannah, Zheng, Wei, Ziogas, Argyrios, Kelemen, Linda E., Berchuck, Andrew, Monteiro, Alvaro N. A., Gayther, Simon A., Narod, Steven A., Pharoah, Paul D. P., Sellers, Thomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Carcinoma, Ovarian Epithelial epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - genetics Female Genes Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Middle Aged Neoplasms, Glandular and Epithelial - epidemiology Neoplasms, Glandular and Epithelial - genetics Odds Ratio Ovarian cancer Ovarian Neoplasms - epidemiology Ovarian Neoplasms - genetics Polymorphism, Single Nucleotide - genetics Risk single-nucleotide polymorphisms White People
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Zusammenfassung:	ABSTRACT Epithelial‐mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene variants contribute to epithelial ovarian carcinoma (EOC) risk have been based on small sample sizes and none have sought replication in an independent population. We screened 15,816 single‐nucleotide polymorphisms (SNPs) in 296 genes in a discovery phase using data from a genome‐wide association study of EOC among women of European ancestry (1,947 cases and 2,009 controls) and identified 793 variants in 278 EMT‐related genes that were nominally (P < 0.05) associated with invasive EOC. These SNPs were then genotyped in a larger study of 14,525 invasive‐cancer patients and 23,447 controls. A P‐value
ISSN:	0741-0395 1098-2272 1098-2272
DOI:	10.1002/gepi.21921