OPTIMA: sensitive and accurate whole-genome alignment of error-prone genomic maps by combinatorial indexing and technology-agnostic statistical analysis

Abstract Background Resolution of complex repeat structures and rearrangements in the assembly and analysis of large eukaryotic genomes is often aided by a combination of high-throughput sequencing and genome-mapping technologies (for example, optical restriction mapping). In particular, mapping tec...

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Veröffentlicht in:	GigaScience 2016-01, Vol.5 (1), p.2-2
Hauptverfasser:	Verzotto, Davide, Teo, Audrey S M, Hillmer, Axel M, Nagarajan, Niranjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alignment Animals Chromosome Mapping - methods Combinations (mathematics) Combinatorial analysis Computational Biology - methods Computer Simulation DNA sequencing Drosophila melanogaster - genetics Error analysis Gene mapping Gene sequencing Genomes Genomic analysis Genomics - methods High-Throughput Nucleotide Sequencing Humans Indexing Mapping Methods Next-generation sequencing Nucleotide sequence Permutations Reproducibility of Results Sensitivity analysis Sequence Alignment - methods Statistical analysis Statistical models Technology assessment
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