ICAM-1 regulates the survival of influenza virus in lung epithelial cells during the early stages of infection

Abstract Intercellular cell adhesion molecule-1 (ICAM-1) is an inducible cell surface glycoprotein that is expressed on many cell types. Influenza virus infection enhanced ICAM-1 expression and messenger RNA levels. Human bronchial epithelial cells (HBEpC) and nasal epithelial cells, on exposure to...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2016-01, Vol.487, p.85-94
Hauptverfasser:	Othumpangat, Sreekumar, Noti, John D, McMillen, Cynthia M, Beezhold, Donald H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchi - immunology Bronchi - virology Cell Line Dogs Epithelial Cells - virology Extracellular Matrix - metabolism Gene Expression Humans Infectious Disease Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H3N2 Subtype - immunology Influenza virus Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - immunology Intercellular cell adhesion molecule Interleukin-1beta - pharmacology Lung epithelial cells Madin Darby Canine Kidney Cells NF-κB Respiratory Mucosa - cytology Respiratory Mucosa - immunology Respiratory Mucosa - virology RNA Interference RNA, Small Interfering Signaling Transcription Factor RelA - biosynthesis Transcription Factor RelA - metabolism
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Zusammenfassung:	Abstract Intercellular cell adhesion molecule-1 (ICAM-1) is an inducible cell surface glycoprotein that is expressed on many cell types. Influenza virus infection enhanced ICAM-1 expression and messenger RNA levels. Human bronchial epithelial cells (HBEpC) and nasal epithelial cells, on exposure to different strains of influenza virus (H1N1, H3N2, and H9N1) showed significant increase in ICAM-1 gene expression ( p
ISSN:	0042-6822 1096-0341
DOI:	10.1016/j.virol.2015.10.005