KyoT2 downregulates airway remodeling in asthma

The typical pathological features of asthma are airway remodeling and airway hyperresponsiveness (AHR). KyoT2, a negative modulator of Notch signaling, has been linked to asthma in several previous studies. However, whether KyoT2 is involved in the regulation of airway remodeling or the modulation o...

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Veröffentlicht in:	International journal of clinical and experimental pathology 2015-01, Vol.8 (11), p.14171-14179
Hauptverfasser:	Hu, Mei, Ou-Yang, Hai-Feng, Han, Xing-Peng, Ti, Xin-Yu, Wu, Chang-Gui
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - metabolism Airway Remodeling Airway Resistance Animals Asthma - genetics Asthma - metabolism Asthma - pathology Asthma - physiopathology Asthma - therapy Basic Helix-Loop-Helix Transcription Factors - metabolism Bronchial Hyperreactivity - genetics Bronchial Hyperreactivity - metabolism Bronchial Hyperreactivity - pathology Bronchial Hyperreactivity - physiopathology Bronchial Hyperreactivity - therapy Disease Models, Animal Fibrosis Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors Homeodomain Proteins - metabolism Intracellular Signaling Peptides and Proteins - biosynthesis Intracellular Signaling Peptides and Proteins - genetics LIM Domain Proteins - biosynthesis LIM Domain Proteins - genetics Lung - metabolism Lung - pathology Lung - physiopathology Male Mice, Inbred BALB C Muscle Proteins - biosynthesis Muscle Proteins - genetics Original Receptor, Notch1 - metabolism Signal Transduction Transcription Factor HES-1
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