Lanosterol Synthase Gene Polymorphisms and Changes in Endogenous Ouabain in the Response to Low Sodium Intake

Circulating levels of endogenous ouabain (EO), a vasopressor hormone of adrenocortical origin, are increased by sodium depletion. Furthermore, lanosterol synthase, an enzyme involved in cholesterol biosynthesis, has a missense polymorphism (rs2254524 V642L) that affects EO biosynthesis in adrenocort...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-02, Vol.67 (2), p.342-348
Hauptverfasser:	Lanzani, Chiara, Gatti, Guido, Citterio, Lorena, Messaggio, Elisabetta, Delli Carpini, Simona, Simonini, Marco, Casamassima, Nunzia, Zagato, Laura, Brioni, Elena, Hamlyn, John M, Manunta, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Blood Pressure - drug effects Blood Pressure - physiology Diet, Sodium-Restricted Enzyme Inhibitors - pharmacokinetics Female Genotype Humans Hypertension - genetics Hypertension - metabolism Hypertension - therapy Intramolecular Transferases - genetics Intramolecular Transferases - metabolism Male Middle Aged Ouabain - pharmacokinetics Polymorphism, Genetic RNA - genetics Young Adult
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