Lanosterol Synthase Gene Polymorphisms and Changes in Endogenous Ouabain in the Response to Low Sodium Intake

Circulating levels of endogenous ouabain (EO), a vasopressor hormone of adrenocortical origin, are increased by sodium depletion. Furthermore, lanosterol synthase, an enzyme involved in cholesterol biosynthesis, has a missense polymorphism (rs2254524 V642L) that affects EO biosynthesis in adrenocort...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-02, Vol.67 (2), p.342-348
Hauptverfasser:	Lanzani, Chiara, Gatti, Guido, Citterio, Lorena, Messaggio, Elisabetta, Delli Carpini, Simona, Simonini, Marco, Casamassima, Nunzia, Zagato, Laura, Brioni, Elena, Hamlyn, John M, Manunta, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Blood Pressure - drug effects Blood Pressure - physiology Diet, Sodium-Restricted Enzyme Inhibitors - pharmacokinetics Female Genotype Humans Hypertension - genetics Hypertension - metabolism Hypertension - therapy Intramolecular Transferases - genetics Intramolecular Transferases - metabolism Male Middle Aged Ouabain - pharmacokinetics Polymorphism, Genetic RNA - genetics Young Adult
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Zusammenfassung:	Circulating levels of endogenous ouabain (EO), a vasopressor hormone of adrenocortical origin, are increased by sodium depletion. Furthermore, lanosterol synthase, an enzyme involved in cholesterol biosynthesis, has a missense polymorphism (rs2254524 V642L) that affects EO biosynthesis in adrenocortical cells. Here, we investigated the hypothesis that lanosterol synthase rs2254524 alleles in vivo impact the blood pressure (BP) and EO responses evoked by a low dietary Na intake (
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.115.06415