Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine

Highlights • CMI responses occurred following administration of an inactivated A/H5N1 vaccine. • High dose vaccine increased the magnitude of CMI response only in the unprimed subjects. • IFN-γ nSFC levels correlated with IFN-γ concentrations in PBMC supernatants.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2016-01, Vol.34 (4), p.547-554
Hauptverfasser:	Mbawuike, Innocent N, Atmar, Robert L, Patel, Shital M, Corry, David B, Winokur, Patricia L, Brady, Rebecca C, Chen, Wilbur H, Edwards, Kathryn M, Creech, C. Buddy, Walter, Emmanuel B, Frey, Sharon E, Belshe, Robert B, Goll, Johannes B, Hill, Heather, Keitel, Wendy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - administration & dosage Adult Advisors Age Age Factors Aged Allergy and Immunology Antigens Avian flu Cell mediated immune response Confidence intervals Cytokine Cytokines Cytokines - immunology Female Granzymes - immunology H5N1 Humans Illnesses Immunity, Cellular Immunization, Secondary Immunoglobulins Inactivated influenza vaccine Infections Influenza A Virus, H5N1 Subtype Influenza Vaccines - administration & dosage Influenza Vaccines - therapeutic use Influenza, Human - prevention & control Interferon-gamma - immunology Leukocytes, Mononuclear - immunology Male Middle Aged Studies Vaccines Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - therapeutic use Young Adult
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Beschreibung
Zusammenfassung:	Highlights • CMI responses occurred following administration of an inactivated A/H5N1 vaccine. • High dose vaccine increased the magnitude of CMI response only in the unprimed subjects. • IFN-γ nSFC levels correlated with IFN-γ concentrations in PBMC supernatants.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.11.055