Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia

We reported before that the minimal alveolar concentration (MAC) of isoflurane is decreased in complex I-deficient mice lacking the NDUFS4 subunit of the respiratory chain (RC) (1.55 and 0.81 % at postnatal (PN) 22–25 days and 1.68 and 0.65 % at PN 31–34 days for wildtype (WT) and CI-deficient KO, r...

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Veröffentlicht in:	Journal of inherited metabolic disease 2016-01, Vol.39 (1), p.59-65
Hauptverfasser:	Manjeri, Ganesh R., Rodenburg, Richard J., Blanchet, Lionel, Roelofs, Suzanne, Nijtmans, Leo G., Smeitink, Jan A., Driessen, Jacques J., Koopman, Werner J. H., Willems, Peter H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Anesthesia - methods Animals Biochemistry Brain - drug effects Brain - metabolism Disease Models, Animal Electron Transport Complex I - deficiency Electron Transport Complex I - metabolism Female Human Genetics Internal Medicine Isoflurane - administration & dosage Male Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Knockout Mitochondria - drug effects Mitochondria - metabolism Original Original Article Pediatrics Pyruvic Acid - metabolism
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