Histopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort

Background: There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time,...

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Veröffentlicht in:	British journal of cancer 2015-12, Vol.113 (11), p.1556-1564
Hauptverfasser:	Bogdanova, Tetiana I, Zurnadzhy, Liudmyla Yu, Nikiforov, Yuri E, Leeman-Neill, Rebecca J, Tronko, Mykola D, Chanock, Stephen, Mabuchi, Kiyohiko, Likhtarov, Ilya A, Kovgan, Leonila M, Drozdovitch, Vladimir, Little, Mark P, Hatch, Maureen, Zablotska, Lydia B, Shpak, Viktor M, McConnell, Robert J, Brenner, Alina V
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/737 692/4028/67/1459/1843 692/4028/67/2324 692/699/67/68 Adolescent Adult Age Factors Biomedical and Life Sciences Biomedicine Blood Vessels - pathology Cancer Research Carcinoma, Papillary - genetics Carcinoma, Papillary - pathology Carcinoma, Papillary - secondary Chernobyl Nuclear Accident Child Child, Preschool Clinical Study Dosimetry Drug dosages Drug Resistance Early Detection of Cancer Endocrinology Epidemiology ETS Translocation Variant 6 Protein Female Histopathology Humans Iodine Iodine Radioisotopes - toxicity Lymphatic Vessels - pathology Male Medical research Medicine Metabolism Molecular Medicine Mutation Neoplasm Invasiveness Nuclear power plants Oncology Paired Box Transcription Factors - genetics PAX8 Transcription Factor Point Mutation PPAR gamma - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ret - genetics Radiation Radiation Dosage Radiation Exposure - adverse effects ras Proteins - genetics Receptor, trkC - genetics Repressor Proteins - genetics Thyroid cancer Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Translocation, Genetic Tumor Burden Tumors Ukraine - ethnology United States Young Adult
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Zusammenfassung:	Background: There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time, and their associations with selected somatic mutations. Methods: This study included 115 PTCs diagnosed in a Ukrainian-American cohort ( n =13 243) during prescreening and four successive thyroid screenings. Of these PTCs, 65 were subjected to somatic mutation profiling. All individuals were
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.2015.372