A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions

A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions

Postinflammatory hyperpigmentation (PIH) is an acquire hypermelanosis after cutaneous inflammation and injury. The aim of the present study was to investigate a natural ingredient with the anti-inflammatory and depigmentation activities into possible applications of postinflammatory hyperpigmentatio...

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Veröffentlicht in:Saudi journal of biological sciences 2016-01, Vol.23 (1), p.9-14
Hauptverfasser: Lee, Seung Jin, Hossaine, M.D. Akil, Park, Seung Chun
Format: Artikel
Sprache:eng
Schlagworte:
Anti-infective agents
Anti-inflammation
Anti-inflammatory agents
Depigmentation
Extract
Inflammation
iNOS
Lespedeza
Lespedeza bicolor
NF-κB
Original
Therapeutic use
Treatment
Tyrosinase activity
الأدوية
الالتهاب
مضادات الالتهاب
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Zusammenfassung:Postinflammatory hyperpigmentation (PIH) is an acquire hypermelanosis after cutaneous inflammation and injury. The aim of the present study was to investigate a natural ingredient with the anti-inflammatory and depigmentation activities into possible applications of postinflammatory hyperpigmentation. Methanol extracts of Lespedeza bicolor and its various fractions inhibited LPS-induced NO production in RAW 264.7 macrophages in a concentration-dependent manner. In particular, the ethyl acetate fraction was shown to be inhibition of NO production (89%) and down-regulation of iNOS mRNA without causing cytotoxicity. In addition, ethyl acetate fraction significantly attenuated LPS-induced NF-κB activation (P
ISSN:1319-562X
2213-7106
DOI:10.1016/j.sjbs.2015.01.016