Presepsin and sepsis-induced acute kidney injury treated with continuous renal replacement therapy: will another promising biomarker bite the dust?

Little information is available on presepsin in patients with kidney dysfunction except that levels tend to increase with digressive glomerular filtration rate and are markedly high in patients with chronic renal failure or receiving hemodialysis [3]. Presepsin clearance may even be higher than expected because the molecule may “stick” to the highly adsorptive membranes incorporated in modern CRRT devices [5]. [...]presepsin cannot be proposed as an accurate and clinically relevant sepsis biomarker until its behavior during CRRT is better specified. Continuous renal replacement therapy Declarations Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.