Metabolic and coagulation effects of citrate: down to the last detail

[...]applying the SIDa approach likely will uncover a substantially higher incidence of severe metabolic alkalosis in the L-CAT patients. [...]the L-CAT investigators attributed the long filter lifespan to a more automated fine-tuning of citrate and calcium dosing. Most important, we found no significant difference between these groups and this was true not only for pH, but also for bicarbonate concentration. [...]even if the overall incidence of alkalosis might have been slightly different using the Stewart-Figge approach, most probably no differences between the study groups would have been detected this way.