A reduction in chronic hepatitis B virus infection prevalence among children in Vietnam demonstrates the importance of vaccination

Highlights • This nationally representative cross-sectional survey sampled children based on a stratified three-stage cluster design. • A total of 6,949 children were included in the survey analyses. • The overall HBsAg prevalence among surveyed children was 2.70%. • Unadjusted HBsAg prevalence amon...

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Veröffentlicht in:	Vaccine 2014-01, Vol.32 (2), p.217-222
Hauptverfasser:	Nguyen, Tran Hien, Vu, Minh Huong, Nguyen, Van Cuong, Nguyen, Lien Huong, Toda, Kohei, Nguyen, Tuyet Nga, Dao, Sang, Wannemuehler, Kathleen A, Hennessey, Karen A
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Allergy and Immunology Applied microbiology Biological and medical sciences Birth dose vaccination blood Caregivers Child childhood children Children & youth chronic hepatitis B confidence interval Confidence intervals Cross-Sectional Studies data collection Ethnicity Female Fundamental and applied biological sciences. Psychology Health facilities Hepatitis hepatitis B antigens Hepatitis B Surface Antigens - blood Hepatitis B Vaccines - therapeutic use Hepatitis B virus Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - prevention & control Human viral diseases Humans Immunization Immunization Programs Immunization, Secondary infants Infections Infectious diseases Male Medical sciences Microbiology Miscellaneous Polls & surveys Population density Prevalence Sample size Seroprevalence Stratigraphy surveys vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vietnam Vietnam - epidemiology Viral diseases Viral hepatitis Virology
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Beschreibung
Zusammenfassung:	Highlights • This nationally representative cross-sectional survey sampled children based on a stratified three-stage cluster design. • A total of 6,949 children were included in the survey analyses. • The overall HBsAg prevalence among surveyed children was 2.70%. • Unadjusted HBsAg prevalence among children with ≥3 doses of hepatitis B vaccine including a birth dose (1.75%) was significantly lower than among children with ≥3 doses of hepatitis B vaccine but lacked a birth dose (2.98%). • Childhood chronic HBV infection prevalence has been markedly reduced in Vietnam due to vaccination.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.11.004