A randomized pilot study of dietary treatments for polycystic ovary syndrome in adolescents

Summary Background Evidence is lacking to recommend one diet over another when treating polycystic ovary syndrome (PCOS). Objectives To obtain preliminary data, comparing the impact of a low‐glycaemic load (LGL) vs. low‐fat (LF) diet on biochemical hyperandrogenism in overweight and obese adolescents with PCOS. To ascertain feasibility of recruiting study participants, in partnership with an adolescent clinic, and implementing dietary interventions. Methods Randomized controlled trial of 19 overweight and obese adolescents with PCOS and not using hormonal contraceptives (HCs). Interventions comprised nutrition education, dietary counselling and cooking workshops to foster adherence to a LGL (45% carbohydrate, 35% fat, 20% protein) or LF (55% carbohydrate, 25% fat, 20% protein) diet over 6 months. Serum bioavailable testosterone was the primary outcome. Results Sixteen (LGL, n = 7; LF, n = 9) participants completed the study. Body fat percentage decreased (P