BCRP protein levels do not differ regionally in adult human livers, but decline in the elderly

The aim of this study was to characterize the ontogeny and variability of the BCRP (ABCG2) transporter in healthy human liver. Levels of BCRP mRNA and protein were determined with q-RT-PCR and western blot in a cohort of 87 human livers aged from 7 days to 87 years. A study of the regional expressio...

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Veröffentlicht in:	Chemico-biological interactions 2015-12, Vol.242, p.203-210
Hauptverfasser:	Riches, Zoe, Abanda, Ngu, Collier, Abby C.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Adolescent Adult Aged Aged, 80 and over Aging - genetics Aging - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Child Child, Preschool Development Female Gene Expression Regulation Geriatrics Humans Infant Infant, Newborn Liver - metabolism Male Middle Aged Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Obesity RNA, Messenger - genetics RNA, Messenger - metabolism Young Adult
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Zusammenfassung:	The aim of this study was to characterize the ontogeny and variability of the BCRP (ABCG2) transporter in healthy human liver. Levels of BCRP mRNA and protein were determined with q-RT-PCR and western blot in a cohort of 87 human livers aged from 7 days to 87 years. A study of the regional expression of BCRP within adult livers was also performed in a nested cohort of 14 individuals with multiple samples per person collected from pre-selected sites. Levels of BCRP mRNA were not significantly different at any age, but protein levels for BCRP were lower in the elderly compared with adults (p
ISSN:	0009-2797 1872-7786
DOI:	10.1016/j.cbi.2015.10.007