Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus

Highlights • Elevated platform stress increases HPA axis function and anxiety-like behaviors. • Ante-stress injections of Oxt blocks the stress response. • Oxt injected in the PVN increase GABAergic neuronal activity and local GABA release. • GABAA receptor antagonism hinders anxiolytic effects of O...

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Veröffentlicht in:	Psychoneuroendocrinology 2016-01, Vol.63, p.50-58
Hauptverfasser:	Smith, Adam S, Tabbaa, Manal, Lei, Kelly, Eastham, Patrick, Butler, Michael J, Linton, Latanya, Altshuler, Randy, Liu, Yan, Wang, Zuoxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - metabolism Arvicolinae Behavior, Animal - drug effects Corticosterone - metabolism Corticotropin-Releasing Hormone - drug effects Corticotropin-Releasing Hormone - metabolism Endocrinology & Metabolism Female GABA-A Receptor Agonists - pharmacology GABA-A Receptor Antagonists - pharmacology Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Immunohistochemistry Microdialysis Oxytocics - pharmacology Oxytocin - pharmacology Paraventricular Hypothalamic Nucleus - metabolism Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Proto-Oncogene Proteins c-fos - drug effects Proto-Oncogene Proteins c-fos - metabolism Psychiatry Receptors, GABA-A - metabolism
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Zusammenfassung:	Highlights • Elevated platform stress increases HPA axis function and anxiety-like behaviors. • Ante-stress injections of Oxt blocks the stress response. • Oxt injected in the PVN increase GABAergic neuronal activity and local GABA release. • GABAA receptor antagonism hinders anxiolytic effects of Oxt.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2015.09.017