Effects of buprenorphine on responses to social stimuli in healthy adults

Highlights • We show that buprenorphine dampens responses to simulated social rejection. • We show that buprenorphine reduces attention to fearful facial expressions, but does not affect attention to happy, sad, or angry faces. • We show that buprenorphine selectively increases ratings of positivity for emotional images with social content. • We observed these effects at a relatively low dose of the drug that does not produce significant euphoria.