New formulation of old aspirin for better delivery

For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demo...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (1), p.140-143
Hauptverfasser:	Kalathil, Akil A, Kumar, Anil, Banik, Bhabatosh, Ruiter, Timothy A, Pathak, Rakesh K, Dhar, Shanta
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogue animal models Animals anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Aspirin Aspirin - administration & dosage Aspirin - analogs & derivatives Aspirin - therapeutic use chemical reactions Cytokines Drug Carriers - chemistry Encapsulation Enrichment hydrophobicity Interleukin-10 - blood Interleukin-10 - immunology Interleukin-6 - blood Interleukin-6 - immunology Male Mathematical models Mice Mice, Inbred BALB C mitochondria Nanoparticles Nanoparticles - chemistry polymers Polymers - chemistry prostaglandin synthase Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - immunology
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Beschreibung
Zusammenfassung:	For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c5cc07316b