B cells in the aging immune system: time to consider B-1 cells

The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B‐1 cell subset is an essential arm of the innate immune system, which...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2015-12, Vol.1362 (1), p.176-187
Hauptverfasser:	Holodick, Nichol E., Rothstein, Thomas L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - immunology Aging - metabolism Animals B cells B-1 cells B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism Biology Bone marrow Diseases Genes Humans Immune system Immune System - immunology Immune System - metabolism Immune systems Immunity, Innate - physiology Immunoglobulin M - immunology Immunoglobulin M - metabolism Maintenance Senescence Spleen
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Beschreibung
Zusammenfassung:	The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B‐1 cell subset is an essential arm of the innate immune system, which in general has been understudied in terms of immune senescence. Here, we review what is currently known about B cells during aging and go on to describe why B‐1 cell biology is an important component of the aging immune system in the context of diseases that most affect the aged population.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/nyas.12825