Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma

The Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) recently performed a genome‐wide association study (GWAS) on esophageal adenocarcinoma (EAC) and Barrett's esophagus. They identified genome‐wide significant association for variants at three genes, namely CRTC1, FOXP1, and BA...

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Veröffentlicht in:	Cancer medicine (Malden, MA) MA), 2015-11, Vol.4 (11), p.1700-1704
Hauptverfasser:	Becker, Jessica, May, Andrea, Gerges, Christian, Anders, Mario, Veits, Lothar, Weise, Katharina, Czamara, Darina, Lyros, Orestis, Manner, Hendrik, Terheggen, Grischa, Venerito, Marino, Noder, Tania, Mayershofer, Rupert, Hofer, Jan‐Hinnerk, Karch, Hans‐Werner, Ahlbrand, Constantin J., Arras, Michael, Hofer, Sebastian, Mangold, Elisabeth, Heilmann‐Heimbach, Stefanie, Heinrichs, Sophie K. M., Hess, Timo, Kiesslich, Ralf, Izbicki, Jakob R., Hölscher, Arnulf H., Bollschweiler, Elfriede, Malfertheiner, Peter, Lang, Hauke, Moehler, Markus, Lorenz, Dietmar, Müller‐Myhsok, Bertram, Ott, Katja, Schmidt, Thomas, Whiteman, David C., Vaughan, Thomas L., Nöthen, Markus M., Hackelsberger, Andreas, Schumacher, Brigitte, Pech, Oliver, Vashist, Yogesh, Vieth, Michael, Weismüller, Josef, Neuhaus, Horst, Rösch, Thomas, Ell, Christian, Gockel, Ines, Schumacher, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - epidemiology Adenocarcinoma - genetics Adolescent Adult Alleles BARX1 Cancer Biology Case-Control Studies esophageal adenocarcinoma Esophageal Neoplasms - epidemiology Esophageal Neoplasms - genetics Female Forkhead Transcription Factors - genetics FOXF1 FOXP1 Genetic Association Studies genetic association study Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genotype Homeodomain Proteins - genetics Humans Male Odds Ratio Polymorphism, Single Nucleotide Repressor Proteins - genetics Transcription Factors - genetics Young Adult
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Zusammenfassung:	The Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) recently performed a genome‐wide association study (GWAS) on esophageal adenocarcinoma (EAC) and Barrett's esophagus. They identified genome‐wide significant association for variants at three genes, namely CRTC1, FOXP1, and BARX1. Furthermore, they replicated an association at the FOXF1 gene that has been previously found in a GWAS on Barrett's esophagus. We aimed at further replicating the association at these and other loci that showed suggestive association with P
ISSN:	2045-7634 2045-7634
DOI:	10.1002/cam4.500