Synthesis of O- and N-alkylated products of 1,2,3,4-tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one

[Display omitted] Efficient syntheses of O- and N-alkylated products of 1,2,3,4-tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one are presented. The O-alkylated analogues were synthesized through a reduction-cyclization cascade and a selective O-alkylation reaction; whereas the N-alkylated analogues were...

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Veröffentlicht in:	Tetrahedron letters 2015-11, Vol.56 (46), p.6472-6474
Hauptverfasser:	Bommagani, Shobanbabu, Lee, Na-Ra, Zhang, Xuan, Dwoskin, Linda P., Zheng, Guangrong
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3,4-Tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one Buchwald coupling Muscarinic acetylcholine receptors Reduction-cyclization cascade Suzuki coupling
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Zusammenfassung:	[Display omitted] Efficient syntheses of O- and N-alkylated products of 1,2,3,4-tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one are presented. The O-alkylated analogues were synthesized through a reduction-cyclization cascade and a selective O-alkylation reaction; whereas the N-alkylated analogues were obtained through a key Buchwald coupling.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2015.09.156