Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children. In order to advance the field of NAFLD, noninvasive imaging methods for measuring liver fat are needed. Advanced magnetic resonance imaging (MRI) has shown great promise for the quantitative assessment of...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2015-06, Vol.61 (6), p.1887-1895
Hauptverfasser:	Schwimmer, Jeffrey B., Middleton, Michael S., Behling, Cynthia, Newton, Kimberly P., Awai, Hannah I., Paiz, Melissa N., Lam, Jessica, Hooker, Jonathan C., Hamilton, Gavin, Fontanesi, John, Sirlin, Claude B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Adolescent Biomarkers Case-Control Studies Child Female Histology Humans Liver - pathology Liver cirrhosis Liver diseases Magnetic Resonance Imaging Male NMR Non-alcoholic Fatty Liver Disease - pathology Nuclear magnetic resonance Prospective Studies
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Zusammenfassung:	Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children. In order to advance the field of NAFLD, noninvasive imaging methods for measuring liver fat are needed. Advanced magnetic resonance imaging (MRI) has shown great promise for the quantitative assessment of hepatic steatosis but has not been validated in children. Therefore, this study was designed to evaluate the correlation and diagnostic accuracy of MRI‐estimated liver proton density fat fraction (PDFF), a biomarker for hepatic steatosis, compared to histologic steatosis grade in children. The study included 174 children with a mean age of 14.0 years. Liver PDFF estimated by MRI was significantly (P
ISSN:	0270-9139 1527-3350
DOI:	10.1002/hep.27666