DSigDB: drug signatures database for gene set analysis

We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an...

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Veröffentlicht in:	Bioinformatics 2015-09, Vol.31 (18), p.3069-3071
Hauptverfasser:	Yoo, Minjae, Shin, Jimin, Kim, Jihye, Ryall, Karen A, Lee, Kyubum, Lee, Sunwon, Jeon, Minji, Kang, Jaewoo, Tan, Aik Choon
Format:	Artikel
Sprache:	eng
Schlagworte:	Applications Notes Bioinformatics Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Computational Biology - methods Computer programs Databases, Pharmaceutical Drug Repositioning Drugs Gene expression Gene Expression Profiling Gene Expression Regulation Genes Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Mutation - genetics Protein Kinase Inhibitors - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Signatures Software
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Zusammenfassung:	We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research. DSigDB is freely available for non-commercial use at http://tanlab.ucdenver.edu/DSigDB. Supplementary data are available at Bioinformatics online. aikchoon.tan@ucdenver.edu.
ISSN:	1367-4803 1367-4811 1460-2059
DOI:	10.1093/bioinformatics/btv313