Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherog...

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Veröffentlicht in:	Methodist DeBakey cardiovascular journal 2015-07, Vol.11 (3), p.166-171
Hauptverfasser:	Sukhovershin, Roman A, Yepuri, Gautham, Ghebremariam, Yohannes T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - drug therapy Atherosclerosis - enzymology Atherosclerosis - genetics Atherosclerosis - pathology Atherosclerosis - physiopathology Cardiovascular Agents - therapeutic use Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Gene Expression Regulation, Enzymologic Humans New Concepts and Therapies for Atherosclerosis Nitric Oxide - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Plaque, Atherosclerotic Signal Transduction - drug effects Vasodilation
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Zusammenfassung:	Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.
ISSN:	1947-6094 1947-6108
DOI:	10.14797/mdcj-11-3-166