Impact of telomere length on survival in classic and variant hairy cell leukemia

Highlights • Telomeres protect the ends of chromosomes but are sometimes shortened in leukemias. • Short telomeres in hairy cell leukemia are associated with decreased overall survival. • Short telomere length correlates with other poor prognosis factors in hairy cell leukemia. • Low telomere length...

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Veröffentlicht in:	Leukemia research 2015-12, Vol.39 (12), p.1360-1366
Hauptverfasser:	Arons, Evgeny, Zhou, Hong, Edelman, Daniel C, Gomez, Allison, Steinberg, Seth M, Petersen, David, Wang, Yonghong, Meltzer, Paul S, Kreitman, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Antimetabolites, Antineoplastic - therapeutic use Chromosomes Combined Modality Therapy DNA damage DNA, Neoplasm - genetics Drug Resistance, Neoplasm Female Gene Rearrangement, B-Lymphocyte, Heavy Chain Hairy cell leukemia Hematology, Oncology and Palliative Medicine Humans Immunoglobulin Heavy Chains - genetics Immunophenotyping Kaplan-Meier Estimate Leukemia, Hairy Cell - classification Leukemia, Hairy Cell - drug therapy Leukemia, Hairy Cell - genetics Leukemia, Hairy Cell - mortality Leukemia, Hairy Cell - surgery Leukocyte Count Male Middle Aged Molecular marker Prognosis Proportional Hazards Models Risk Factors Splenectomy Telomere Telomere - ultrastructure Telomere Homeostasis Telomere Shortening
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Beschreibung
Zusammenfassung:	Highlights • Telomeres protect the ends of chromosomes but are sometimes shortened in leukemias. • Short telomeres in hairy cell leukemia are associated with decreased overall survival. • Short telomere length correlates with other poor prognosis factors in hairy cell leukemia. • Low telomere length should be studied further in this disease.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.09.015