Translational deficiencies in antibacterial discovery and new screening paradigms
Highlights • Appreciation for bacterial physiology during infection will impact discovery. • Following CLSI guidelines can prevent accurate prediction of compound utility. • New antibacterial screening strategies may identify new drug targets/pathways.
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| Veröffentlicht in: | Current opinion in microbiology 2015-10, Vol.27, p.108-113 |
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| container_title | Current opinion in microbiology |
| container_volume | 27 |
| creator | Dunman, Paul M Tomaras, Andrew P |
| description | Highlights • Appreciation for bacterial physiology during infection will impact discovery. • Following CLSI guidelines can prevent accurate prediction of compound utility. • New antibacterial screening strategies may identify new drug targets/pathways. |
| doi_str_mv | 10.1016/j.mib.2015.08.006 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1369-5274 |
| ispartof | Current opinion in microbiology, 2015-10, Vol.27, p.108-113 |
| issn | 1369-5274 1879-0364 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use antibiotics Bacterial Infections - drug therapy Bacterial Infections - microbiology Drug Discovery Drug Resistance, Multiple human health Humans infectious diseases Microbial Sensitivity Tests multiple drug resistance pathogens Pathology screening translation (genetics) Translational Medical Research - methods |
| title | Translational deficiencies in antibacterial discovery and new screening paradigms |
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