Translational deficiencies in antibacterial discovery and new screening paradigms

Translational deficiencies in antibacterial discovery and new screening paradigms

Highlights • Appreciation for bacterial physiology during infection will impact discovery. • Following CLSI guidelines can prevent accurate prediction of compound utility. • New antibacterial screening strategies may identify new drug targets/pathways.

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Bibliographische Detailangaben
Veröffentlicht in:Current opinion in microbiology 2015-10, Vol.27, p.108-113
Hauptverfasser: Dunman, Paul M, Tomaras, Andrew P
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
antibiotics
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Drug Discovery
Drug Resistance, Multiple
human health
Humans
infectious diseases
Microbial Sensitivity Tests
multiple drug resistance
pathogens
Pathology
screening
translation (genetics)
Translational Medical Research - methods
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Beschreibung
Zusammenfassung:Highlights • Appreciation for bacterial physiology during infection will impact discovery. • Following CLSI guidelines can prevent accurate prediction of compound utility. • New antibacterial screening strategies may identify new drug targets/pathways.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2015.08.006