Effect of Lymph Node Count on Pathological Stage III Rectal Cancer with Preoperative Radiotherapy
Lymph node (LN) status after surgery for rectal cancer is affected by preoperative radiotherapy. The purpose of this study was to perform a population-based evaluation of the impact of pathologic LN status after neoadjuvant radiotherapy on survival. A total of 1,650 patients receiving neoadjuvant ch...
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| Veröffentlicht in: | Scientific reports 2015-11, Vol.5 (1), p.16990-16990, Article 16990 |
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| description | Lymph node (LN) status after surgery for rectal cancer is affected by preoperative radiotherapy. The purpose of this study was to perform a population-based evaluation of the impact of pathologic LN status after neoadjuvant radiotherapy on survival. A total of 1,650 patients receiving neoadjuvant chemotherapy in Surveillance, Epidemiology and End Results Program (SEER)-registered ypIII stage rectal cancer was analyzed. We identified the optimal cutoff for retrieved LNs as 10 (χ2 = 14.006,
P
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P
<
0.001
), which was validated as an independent prognosis factors in a Cox regression model. Further analysis showed that the LN count was only a prognosis factor with the number from 8 to 16(except for 13).After the number 16, the 5-year survival rate decreased gradually. Collectively, our results confirmed that the number of LNs in yp III stage rectal patients was a prognosis factor only with the numbers from 8 to 16(except for 13). Using the total mesorectal excision technique with an adequate pathologic examination, a large number of LNs retrieved (≥17) might indicate worse tumor response grade and poorer survival.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep16990</identifier><identifier>PMID: 26582242</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/409 ; 692/699/67/1059/485 ; Adult ; Aged ; Aged, 80 and over ; Cancer ; Chemotherapy ; Colorectal cancer ; Databases as Topic ; Epidemiology ; Female ; Humanities and Social Sciences ; Humans ; Lymph ; Lymph nodes ; Lymph Nodes - pathology ; Lymphatic system ; Male ; Medical prognosis ; Middle Aged ; multidisciplinary ; Multivariate Analysis ; Neoplasm Staging ; Preoperative Care ; Prognosis ; Radiation therapy ; Rectal Neoplasms - pathology ; Rectal Neoplasms - radiotherapy ; Rectal Neoplasms - surgery ; Rectum ; Registries ; Science ; SEER Program ; Surgery ; Survival ; Survival Analysis ; Young Adult</subject><ispartof>Scientific reports, 2015-11, Vol.5 (1), p.16990-16990, Article 16990</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Nov 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-fdf2c14d728139ec735afc33fffeaeea6f53312672322a6029ee941d23d8695a3</citedby><cites>FETCH-LOGICAL-c438t-fdf2c14d728139ec735afc33fffeaeea6f53312672322a6029ee941d23d8695a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652213/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652213/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26582242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Qingguo</creatorcontrib><creatorcontrib>Liang, Lei</creatorcontrib><creatorcontrib>Gan, Lu</creatorcontrib><creatorcontrib>Cai, Guoxiang</creatorcontrib><creatorcontrib>Li, Xinxiang</creatorcontrib><creatorcontrib>Cai, Sanjun</creatorcontrib><title>Effect of Lymph Node Count on Pathological Stage III Rectal Cancer with Preoperative Radiotherapy</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Lymph node (LN) status after surgery for rectal cancer is affected by preoperative radiotherapy. The purpose of this study was to perform a population-based evaluation of the impact of pathologic LN status after neoadjuvant radiotherapy on survival. A total of 1,650 patients receiving neoadjuvant chemotherapy in Surveillance, Epidemiology and End Results Program (SEER)-registered ypIII stage rectal cancer was analyzed. We identified the optimal cutoff for retrieved LNs as 10 (χ2 = 14.006,
P
<
0.001
), which was validated as an independent prognosis factors in a Cox regression model. Further analysis showed that the LN count was only a prognosis factor with the number from 8 to 16(except for 13).After the number 16, the 5-year survival rate decreased gradually. Collectively, our results confirmed that the number of LNs in yp III stage rectal patients was a prognosis factor only with the numbers from 8 to 16(except for 13). Using the total mesorectal excision technique with an adequate pathologic examination, a large number of LNs retrieved (≥17) might indicate worse tumor response grade and poorer survival.</description><subject>692/308/409</subject><subject>692/699/67/1059/485</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Databases as Topic</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Lymph</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Preoperative Care</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Rectal Neoplasms - surgery</subject><subject>Rectum</subject><subject>Registries</subject><subject>Science</subject><subject>SEER Program</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkU9P3DAQxa2qqCDg0C9QWeqlIC3E4yQbXyqhFaUrrQDx52xNnfEmKBuntgPab1-jpaul9cX2zM_Pb_QY-yyyM5HJ6jx4GkSpVPaBHUCWFxOQAB93zvvsOISnLK0CVC7UJ7YPZVEB5HDA8NJaMpE7yxfr1dDwa1cTn7mxT7We32JsXOeWrcGO30dcEp_P5_wuPUmFGfaGPH9pY8NvPbmBPMb2mfgd1q2LTboO6yO2Z7ELdPy2H7LHH5cPs5-Txc3VfHaxmJhcVnFiawtG5PUUKiEVmaks0BopbfKHRFjaQkoB5fR1JCwzUERpmhpkXZWqQHnIvm90h_HXimpDffTY6cG3K_Rr7bDV7zt92-ile9Z5WQAImQS-vQl493ukEPWqDYa6DntyY9AiWVKZVAAJ_foP-uRG36fxtKiUqiAFUyXqZEMZ70KKyW7NiEy_Zqe32SX2y677Lfk3qQScboCQWv2S_M6X_6n9Af-Woyo</recordid><startdate>20151119</startdate><enddate>20151119</enddate><creator>Li, Qingguo</creator><creator>Liang, Lei</creator><creator>Gan, Lu</creator><creator>Cai, Guoxiang</creator><creator>Li, Xinxiang</creator><creator>Cai, Sanjun</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151119</creationdate><title>Effect of Lymph Node Count on Pathological Stage III Rectal Cancer with Preoperative Radiotherapy</title><author>Li, Qingguo ; Liang, Lei ; Gan, Lu ; Cai, Guoxiang ; Li, Xinxiang ; Cai, Sanjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-fdf2c14d728139ec735afc33fffeaeea6f53312672322a6029ee941d23d8695a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/308/409</topic><topic>692/699/67/1059/485</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Databases as Topic</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Lymph</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Preoperative Care</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Rectal Neoplasms - surgery</topic><topic>Rectum</topic><topic>Registries</topic><topic>Science</topic><topic>SEER Program</topic><topic>Surgery</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Qingguo</creatorcontrib><creatorcontrib>Liang, Lei</creatorcontrib><creatorcontrib>Gan, Lu</creatorcontrib><creatorcontrib>Cai, Guoxiang</creatorcontrib><creatorcontrib>Li, Xinxiang</creatorcontrib><creatorcontrib>Cai, Sanjun</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Journals (ProQuest Database)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Qingguo</au><au>Liang, Lei</au><au>Gan, Lu</au><au>Cai, Guoxiang</au><au>Li, Xinxiang</au><au>Cai, Sanjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Lymph Node Count on Pathological Stage III Rectal Cancer with Preoperative Radiotherapy</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-11-19</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>16990</spage><epage>16990</epage><pages>16990-16990</pages><artnum>16990</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Lymph node (LN) status after surgery for rectal cancer is affected by preoperative radiotherapy. The purpose of this study was to perform a population-based evaluation of the impact of pathologic LN status after neoadjuvant radiotherapy on survival. A total of 1,650 patients receiving neoadjuvant chemotherapy in Surveillance, Epidemiology and End Results Program (SEER)-registered ypIII stage rectal cancer was analyzed. We identified the optimal cutoff for retrieved LNs as 10 (χ2 = 14.006,
P
<
0.001
), which was validated as an independent prognosis factors in a Cox regression model. Further analysis showed that the LN count was only a prognosis factor with the number from 8 to 16(except for 13).After the number 16, the 5-year survival rate decreased gradually. Collectively, our results confirmed that the number of LNs in yp III stage rectal patients was a prognosis factor only with the numbers from 8 to 16(except for 13). Using the total mesorectal excision technique with an adequate pathologic examination, a large number of LNs retrieved (≥17) might indicate worse tumor response grade and poorer survival.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26582242</pmid><doi>10.1038/srep16990</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/409 692/699/67/1059/485 Adult Aged Aged, 80 and over Cancer Chemotherapy Colorectal cancer Databases as Topic Epidemiology Female Humanities and Social Sciences Humans Lymph Lymph nodes Lymph Nodes - pathology Lymphatic system Male Medical prognosis Middle Aged multidisciplinary Multivariate Analysis Neoplasm Staging Preoperative Care Prognosis Radiation therapy Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Rectum Registries Science SEER Program Surgery Survival Survival Analysis Young Adult |
| title | Effect of Lymph Node Count on Pathological Stage III Rectal Cancer with Preoperative Radiotherapy |
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