Effect of Lymph Node Count on Pathological Stage III Rectal Cancer with Preoperative Radiotherapy

Lymph node (LN) status after surgery for rectal cancer is affected by preoperative radiotherapy. The purpose of this study was to perform a population-based evaluation of the impact of pathologic LN status after neoadjuvant radiotherapy on survival. A total of 1,650 patients receiving neoadjuvant ch...

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Veröffentlicht in:	Scientific reports 2015-11, Vol.5 (1), p.16990-16990, Article 16990
Hauptverfasser:	Li, Qingguo, Liang, Lei, Gan, Lu, Cai, Guoxiang, Li, Xinxiang, Cai, Sanjun
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/409 692/699/67/1059/485 Adult Aged Aged, 80 and over Cancer Chemotherapy Colorectal cancer Databases as Topic Epidemiology Female Humanities and Social Sciences Humans Lymph Lymph nodes Lymph Nodes - pathology Lymphatic system Male Medical prognosis Middle Aged multidisciplinary Multivariate Analysis Neoplasm Staging Preoperative Care Prognosis Radiation therapy Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Rectum Registries Science SEER Program Surgery Survival Survival Analysis Young Adult
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Zusammenfassung:	Lymph node (LN) status after surgery for rectal cancer is affected by preoperative radiotherapy. The purpose of this study was to perform a population-based evaluation of the impact of pathologic LN status after neoadjuvant radiotherapy on survival. A total of 1,650 patients receiving neoadjuvant chemotherapy in Surveillance, Epidemiology and End Results Program (SEER)-registered ypIII stage rectal cancer was analyzed. We identified the optimal cutoff for retrieved LNs as 10 (χ2 = 14.006, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep16990