K13-Propeller Polymorphisms in Plasmodium falciparum Isolates from Patients in Mayotte in 2013 and 2014

Plasmodium falciparum isolates were collected from 29 malaria patients treated with artemether-lumefantrine in Mayotte in 2013 and 2014. Twenty-four cases (83%) consisted of imported malaria. Seventeen percent of the isolates presented mutations in one of the six K13-propeller blades (N490H, F495L,...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2015-12, Vol.59 (12), p.7878-7881
Hauptverfasser:	Torrentino-Madamet, Marylin, Collet, Louis, Lepère, Jean François, Benoit, Nicolas, Amalvict, Rémy, Ménard, Didier, Pradines, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials Antimalarials - pharmacology Artemether, Lumefantrine Drug Combination Artemisinins Artemisinins - pharmacology Comoros Comoros - epidemiology Drug Combinations Drug Resistance Drug Resistance - genetics Epidemiology and Surveillance Ethanolamines Ethanolamines - pharmacology Female Fluorenes Fluorenes - pharmacology Human health and pathology Humans Infectious diseases Life Sciences Malaria, Falciparum Malaria, Falciparum - drug therapy Malaria, Falciparum - epidemiology Malaria, Falciparum - parasitology Male Mutation Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Plasmodium falciparum - isolation & purification Polymorphism, Genetic Protozoan Proteins Protozoan Proteins - genetics Protozoan Proteins - metabolism Retrospective Studies
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Zusammenfassung:	Plasmodium falciparum isolates were collected from 29 malaria patients treated with artemether-lumefantrine in Mayotte in 2013 and 2014. Twenty-four cases (83%) consisted of imported malaria. Seventeen percent of the isolates presented mutations in one of the six K13-propeller blades (N490H, F495L, N554H/K, and E596G). A total of 23.8% of the isolates from the Union of Comoros showed K13-propeller polymorphisms. Three of the 18 isolates (16.7%) from Grande Comore showed polymorphisms (N490H, N554K, and E596G).
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.01251-15