Correlation between serum CEA levels and EGFR mutations in Chinese nonsmokers with lung adenocarcinoma

Aim: To evaluate the relationship between epidermal growth factor receptor (EGFR) mutations and serum carcinoembryonic antigen (CEA) levels in Chinese nonsmokers with pulmonary adenocarcinoma. Methods: We sequenced exons 18-21 of the EGFR gene in 98 cases. The patients were divided into two groups b...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta pharmacologica Sinica 2014-03, Vol.35 (3), p.373-380
Hauptverfasser: Jin, Bo, Dong, Yu, Wang, Hui-min, Huang, Jin-su, Han, Bao-hui
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aim: To evaluate the relationship between epidermal growth factor receptor (EGFR) mutations and serum carcinoembryonic antigen (CEA) levels in Chinese nonsmokers with pulmonary adenocarcinoma. Methods: We sequenced exons 18-21 of the EGFR gene in 98 cases. The patients were divided into two groups based on their pre- treatment serum CEA levels (below or above 5 n~/mL) for analyzing the correlations with EGFR mutations. Results: Sixty-seven cases harbored EGFR mutations. The rates of EGFR mutations and exon 19 mutations in the high-CEA group (78.2% and 49.1%, respectively) were significantly higher than those in the Iow-CEA group (55.8% and 20.9%, respectively). Serum CEA levels were found to be the only independent predictor of EGFR mutation (OR 2.837; 95% CI: 1.178-6.829) and exon 19 mutation (OR 3.618; 95% CI: 1.319-9.918). Furthermore, a higher serum CEA level was associated with a higher EGFR mutation rate and a higher exon 19 mutation rate: patients with serum CEA levels 〈5 ng/mL, 〉5 and 〈20 ng/mL, 〉20 ng/mL showed the EGFR mutation rate of 55.8%, 74.1%, 82.1%, respectively, and the exon :19 mutation rate of 20.9%, 40.7%, 57.1%, respectively. Patients with EGFR mutations displayed a significantly higher incidence of abnormal serum CEA levels (〉5 ng/mL) than patients without EGFR mutations (64.2% vs 38.7%). Conclusion: Elevated serum CEA levels predict the presence of EGFR gene mutations in Chinese nonsmokers with pulmonary adenocarcinoma.
ISSN:1671-4083
1745-7254
DOI:10.1038/aps.2013.164