Safety and efficacy of high-dose tamoxifen and sulindac for desmoid tumor in children: Results of a Children's Oncology Group (COG) Phase II Study

Background Desmoid fibromatosis (desmoid tumor, DT) is a soft tissue neoplasm prone to recurrence despite complete surgical resection. Numerous small retrospective reports suggest that non‐cytotoxic chemotherapy using tamoxifen and sulindac may be effective for DT. We evaluated the safety and effica...

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Veröffentlicht in:	Pediatric blood & cancer 2013-07, Vol.60 (7), p.1108-1112
Hauptverfasser:	Skapek, Stephen X., Anderson, James R., Hill, D. Ashley, Henry, David, Spunt, Sheri L., Meyer, William, Kao, Simon, Hoffer, Fredric A., Grier, Holcombe E., Hawkins, Douglas S., Raney, R. Beverly
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects chemotherapy Child desmoid-type fibromatosis Disease-Free Survival Female Fibromatosis, Aggressive - drug therapy Fibromatosis, Aggressive - mortality Hematology Humans Male Oncology Pediatrics sulindac Sulindac - administration & dosage Sulindac - adverse effects tamoxifen Tamoxifen - administration & dosage Tamoxifen - adverse effects
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Zusammenfassung:	Background Desmoid fibromatosis (desmoid tumor, DT) is a soft tissue neoplasm prone to recurrence despite complete surgical resection. Numerous small retrospective reports suggest that non‐cytotoxic chemotherapy using tamoxifen and sulindac may be effective for DT. We evaluated the safety and efficacy of tamoxifen and sulindac in a prospective phase II study within the Children's Oncology Group. Procedures Eligible patients were
ISSN:	1545-5009 1545-5017
DOI:	10.1002/pbc.24457