Brief Report: Dolutegravir Plus Abacavir/Lamivudine for the Treatment of HIV-1 Infection in Antiretroviral Therapy-Naive Patients: Week 96 and Week 144 Results From the SINGLE Randomized Clinical Trial

The SINGLE study was a randomized, double-blind, noninferiority study that evaluated the safety and efficacy of 50 mg dolutegravir + abacavir/lamivudine versus efavirenz/tenofovir/emtricitabine in 833 ART-naive HIV-1 + participants. Of 833 randomized participants, 71% in the dolutegravir + abacavir/...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2015-12, Vol.70 (5), p.515-519
Hauptverfasser:	Walmsley, Sharon, Baumgarten, Axel, Berenguer, Juan, Felizarta, Franco, Florence, Eric, Khuong-Josses, Marie-Aude, Kilby, J Michael, Lutz, Thomas, Podzamczer, Daniel, Portilla, Joaquin, Roth, Norman, Wong, Deborah, Granier, Catherine, Wynne, Brian, Pappa, Keith
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - administration & dosage Anti-HIV Agents - therapeutic use Antiretroviral drugs Clinical Science Clinical trials Dideoxynucleosides - administration & dosage Dideoxynucleosides - therapeutic use Double-Blind Method Drug Administration Schedule Drug Combinations Drug Therapy, Combination Heterocyclic Compounds, 3-Ring - administration & dosage Heterocyclic Compounds, 3-Ring - therapeutic use HIV HIV Infections - drug therapy HIV-1 Human immunodeficiency virus Human immunodeficiency virus 1 Humans Lamivudine - administration & dosage Lamivudine - therapeutic use
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Beschreibung
Zusammenfassung:	The SINGLE study was a randomized, double-blind, noninferiority study that evaluated the safety and efficacy of 50 mg dolutegravir + abacavir/lamivudine versus efavirenz/tenofovir/emtricitabine in 833 ART-naive HIV-1 + participants. Of 833 randomized participants, 71% in the dolutegravir + abacavir/lamivudine arm and 63% in the efavirenz/tenofovir/emtricitabine arm maintained viral loads of
ISSN:	1525-4135 1944-7884
DOI:	10.1097/QAI.0000000000000790