An analysis of cochlear response harmonics: Contribution of neural excitation
In this report an analysis of cochlear response harmonics is developed to derive a mathematical function to estimate the gross mechanics involved in the in vivo transfer of acoustic sound into neural excitation (f(Tr)). In a simulation it is shown that the harmonic distortion from a nonlinear system...
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| Veröffentlicht in: | The Journal of the Acoustical Society of America 2015-11, Vol.138 (5), p.2957-2963 |
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| container_title | The Journal of the Acoustical Society of America |
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| creator | Chertoff, M E Kamerer, A M Peppi, M Lichtenhan, J T |
| description | In this report an analysis of cochlear response harmonics is developed to derive a mathematical function to estimate the gross mechanics involved in the in vivo transfer of acoustic sound into neural excitation (f(Tr)). In a simulation it is shown that the harmonic distortion from a nonlinear system can be used to estimate the nonlinearity, supporting the next phase of the experiment: Applying the harmonic analysis to physiologic measurements to derive estimates of the unknown, in vivo f(Tr). From gerbil ears, estimates of f(Tr) were derived from cochlear response measurements made with an electrode at the round window niche from 85 Hz tone bursts. Estimates of f(Tr) before and after inducing auditory neuropathy-loss of auditory nerve responses with preserved hair cell responses from neurotoxic treatment with ouabain-showed that the neural excitation from low-frequency tones contributes to the magnitude of f(Tr) but not the sigmoidal, saturating, nonlinear morphology. |
| doi_str_mv | 10.1121/1.4934556 |
| format | Article |
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Estimates of f(Tr) before and after inducing auditory neuropathy-loss of auditory nerve responses with preserved hair cell responses from neurotoxic treatment with ouabain-showed that the neural excitation from low-frequency tones contributes to the magnitude of f(Tr) but not the sigmoidal, saturating, nonlinear morphology.</description><identifier>ISSN: 0001-4966</identifier><identifier>EISSN: 1520-8524</identifier><identifier>DOI: 10.1121/1.4934556</identifier><identifier>PMID: 26627769</identifier><language>eng</language><publisher>United States: Acoustical Society of America</publisher><subject>Acoustics ; Action Potentials ; Animals ; Auditory Pathways - physiology ; Cochlea - physiology ; Cochlear Nerve - drug effects ; Cochlear Nerve - physiology ; Computer Simulation ; Female ; Gerbillinae - physiology ; Hair Cells, Auditory - physiology ; Mechanotransduction, Cellular ; Models, Neurological ; Neurotoxins - toxicity ; Nonlinear Dynamics ; Ouabain - toxicity ; Psychological and Physiological Acoustics</subject><ispartof>The Journal of the Acoustical Society of America, 2015-11, Vol.138 (5), p.2957-2963</ispartof><rights>Copyright © 2015 Acoustical Society of America 2015 Acoustical Society of America</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-8f6e9b410678ba858dc02c63fa13ec2c73f8c6bb16be3aba385e27fa3f0d08573</citedby><cites>FETCH-LOGICAL-c375t-8f6e9b410678ba858dc02c63fa13ec2c73f8c6bb16be3aba385e27fa3f0d08573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>207,208,230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26627769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chertoff, M E</creatorcontrib><creatorcontrib>Kamerer, A M</creatorcontrib><creatorcontrib>Peppi, M</creatorcontrib><creatorcontrib>Lichtenhan, J T</creatorcontrib><title>An analysis of cochlear response harmonics: Contribution of neural excitation</title><title>The Journal of the Acoustical Society of America</title><addtitle>J Acoust Soc Am</addtitle><description>In this report an analysis of cochlear response harmonics is developed to derive a mathematical function to estimate the gross mechanics involved in the in vivo transfer of acoustic sound into neural excitation (f(Tr)). In a simulation it is shown that the harmonic distortion from a nonlinear system can be used to estimate the nonlinearity, supporting the next phase of the experiment: Applying the harmonic analysis to physiologic measurements to derive estimates of the unknown, in vivo f(Tr). From gerbil ears, estimates of f(Tr) were derived from cochlear response measurements made with an electrode at the round window niche from 85 Hz tone bursts. Estimates of f(Tr) before and after inducing auditory neuropathy-loss of auditory nerve responses with preserved hair cell responses from neurotoxic treatment with ouabain-showed that the neural excitation from low-frequency tones contributes to the magnitude of f(Tr) but not the sigmoidal, saturating, nonlinear morphology.</description><subject>Acoustics</subject><subject>Action Potentials</subject><subject>Animals</subject><subject>Auditory Pathways - physiology</subject><subject>Cochlea - physiology</subject><subject>Cochlear Nerve - drug effects</subject><subject>Cochlear Nerve - physiology</subject><subject>Computer Simulation</subject><subject>Female</subject><subject>Gerbillinae - physiology</subject><subject>Hair Cells, Auditory - physiology</subject><subject>Mechanotransduction, Cellular</subject><subject>Models, Neurological</subject><subject>Neurotoxins - toxicity</subject><subject>Nonlinear Dynamics</subject><subject>Ouabain - toxicity</subject><subject>Psychological and Physiological Acoustics</subject><issn>0001-4966</issn><issn>1520-8524</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LAzEQhoMotlYP_gHJ1cPWfG_Wg1CKX1DxoueQpImNbJOSbMX-e7e0Fj0NM_PO-w4PAJcYjTEm-AaPWUMZ5-IIDDEnqJKcsGMwRAjhijVCDMBZKZ99yyVtTsGACEHqWjRD8DKJUEfdbkooMHlok120TmeYXVmlWBxc6LxMMdhyC6cpdjmYdRdS3IqjW2fdQvdtQ6e3w3Nw4nVb3MW-jsD7w_3b9KmavT4-TyezytKad5X0wjWGYSRqabTkcm4RsYJ6jamzxNbUSyuMwcI4qo2mkjtSe009miPJazoCdzvf1dos3dy6_i_dqlUOS503Kumg_m9iWKiP9KWYYAz3sEbgemdgcyolO3-4xUhtmSqs9kx77dXfsIPyFyL9AQsVc7Y</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Chertoff, M E</creator><creator>Kamerer, A M</creator><creator>Peppi, M</creator><creator>Lichtenhan, J T</creator><general>Acoustical Society of America</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201511</creationdate><title>An analysis of cochlear response harmonics: Contribution of neural excitation</title><author>Chertoff, M E ; Kamerer, A M ; Peppi, M ; Lichtenhan, J T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-8f6e9b410678ba858dc02c63fa13ec2c73f8c6bb16be3aba385e27fa3f0d08573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acoustics</topic><topic>Action Potentials</topic><topic>Animals</topic><topic>Auditory Pathways - physiology</topic><topic>Cochlea - physiology</topic><topic>Cochlear Nerve - drug effects</topic><topic>Cochlear Nerve - physiology</topic><topic>Computer Simulation</topic><topic>Female</topic><topic>Gerbillinae - physiology</topic><topic>Hair Cells, Auditory - physiology</topic><topic>Mechanotransduction, Cellular</topic><topic>Models, Neurological</topic><topic>Neurotoxins - toxicity</topic><topic>Nonlinear Dynamics</topic><topic>Ouabain - toxicity</topic><topic>Psychological and Physiological Acoustics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chertoff, M E</creatorcontrib><creatorcontrib>Kamerer, A M</creatorcontrib><creatorcontrib>Peppi, M</creatorcontrib><creatorcontrib>Lichtenhan, J T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of the Acoustical Society of America</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chertoff, M E</au><au>Kamerer, A M</au><au>Peppi, M</au><au>Lichtenhan, J T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An analysis of cochlear response harmonics: Contribution of neural excitation</atitle><jtitle>The Journal of the Acoustical Society of America</jtitle><addtitle>J Acoust Soc Am</addtitle><date>2015-11</date><risdate>2015</risdate><volume>138</volume><issue>5</issue><spage>2957</spage><epage>2963</epage><pages>2957-2963</pages><issn>0001-4966</issn><eissn>1520-8524</eissn><abstract>In this report an analysis of cochlear response harmonics is developed to derive a mathematical function to estimate the gross mechanics involved in the in vivo transfer of acoustic sound into neural excitation (f(Tr)). 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| source | MEDLINE; AIP Journals Complete; Alma/SFX Local Collection; AIP Acoustical Society of America |
| subjects | Acoustics Action Potentials Animals Auditory Pathways - physiology Cochlea - physiology Cochlear Nerve - drug effects Cochlear Nerve - physiology Computer Simulation Female Gerbillinae - physiology Hair Cells, Auditory - physiology Mechanotransduction, Cellular Models, Neurological Neurotoxins - toxicity Nonlinear Dynamics Ouabain - toxicity Psychological and Physiological Acoustics |
| title | An analysis of cochlear response harmonics: Contribution of neural excitation |
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