SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positiv...

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Veröffentlicht in:	Scientific reports 2015-11, Vol.5 (1), p.16396-16396, Article 16396
Hauptverfasser:	Ao, Qilin, Su, Wenjing, Guo, Shuang, Cai, Lei, Huang, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/2 13/89 42/109 42/35 631/208/200 692/4028/67/1517/1709 Antineoplastic Agents - pharmacology Cell Hypoxia Cell Line, Tumor Cisplatin - pharmacology Cysteine Endopeptidases Drug Resistance, Neoplasm - genetics Endopeptidases - genetics Endopeptidases - metabolism Female Gene Expression Regulation, Neoplastic - drug effects Humanities and Social Sciences Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism multidisciplinary Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Science Sumoylation
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Zusammenfassung:	Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1α by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1α and plays a negative role in ovarian cancer chemotherapy.
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep16396