Effect of Peginterferon or Ribavirin Dosing on Efficacy of Therapy With Telaprevir in Treatment-Experienced Patients With Chronic Hepatitis C and Advanced Liver Fibrosis: A Multicenter Cohort Study

We investigated the safety, efficacy, and impact of ribavirin and peginterferon dose reduction on complete early virologic response and sustained virologic response (SVR) to triple therapy with telaprevir in treatment-experienced patients with advanced liver fibrosis.Treatment was initiated for 211...

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Veröffentlicht in:	Medicine (Baltimore) 2015-09, Vol.94 (38), p.e1411-e1411
Hauptverfasser:	Janczewska, Ewa, Flisiak, Robert, Zarebska-Michaluk, Dorota, Kozielewicz, Dorota, Berak, Hanna, Dobracka, Beata, Librant-Suska, Marta, Lojewski, Wladyslaw, Jurczyk, Krzysztof, Musialik, Joanna, Postawa-Klosińska, Barbara, Wroblewski, Jacek, Augustyniak, Krystyna, Dudziak, Marek, Olszok, Iwona, Ruszala, Agata, Pisula, Arkadiusz, Lapinski, Tadeusz, Kryczka, Wieslaw, Horban, Andrzej, Dobracki, Witold
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Cohort Studies Dose-Response Relationship, Drug Drug Carriers Drug Monitoring Drug Substitution - methods Drug Therapy, Combination Female Hepatitis C, Chronic - complications Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - epidemiology Humans Interferon alpha-2 Interferon-alpha - administration & dosage Interferon-alpha - adverse effects Liver Cirrhosis - etiology Liver Cirrhosis - pathology Liver Function Tests - methods Male Middle Aged Observational Study (Strobe Compliant) Oligopeptides - administration & dosage Oligopeptides - adverse effects Patient Acuity Poland - epidemiology Polyethylene Glycols - administration & dosage Polyethylene Glycols - adverse effects Recombinant Proteins - administration & dosage Recombinant Proteins - adverse effects Ribavirin - administration & dosage Ribavirin - adverse effects Treatment Outcome
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Zusammenfassung:	We investigated the safety, efficacy, and impact of ribavirin and peginterferon dose reduction on complete early virologic response and sustained virologic response (SVR) to triple therapy with telaprevir in treatment-experienced patients with advanced liver fibrosis.Treatment was initiated for 211 patients who failed treatment with peginterferon and ribavirin, with bridging fibrosis (F3, n = 68) or cirrhosis (F4, n = 143), including 103 (49%) null-responders (NR), 30 (14%) partial responders (PR), and 78 (37%) relapsers (REL). Impaired liver function (ILF) platelets
ISSN:	0025-7974 1536-5964
DOI:	10.1097/MD.0000000000001411