Increased excitability and excitatory synaptic transmission during in vitro ischemia in the neonatal mouse hippocampus

Highlights • CA1 pyramidal neurons’ membrane properties are altered during oxygen-glucose deprivation leading to increased excitability. • Excitatory synaptic transmission is increased during both oxygen-glucose deprivation and reoxygenation. • Excitatory postsynaptic current amplitude is unchanged indicating increased release and presynaptic mechanisms. • These mechanisms may represent key steps in the progression from ischemic insult to acute seizure in the neonatal brain.