Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity

The increasing incidence of obesity accentuates the importance of identifying mechanisms and optimal therapeutic strategies for patients with heart failure (HF) in relation to obesity status. Here, we investigated the association between plasma level of apelin, an adipocyte-derived factor and clinic...

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Veröffentlicht in:	Scientific reports 2015-11, Vol.5 (1), p.16104-16104, Article 16104
Hauptverfasser:	Boal, Frederic, Roumegoux, Jessica, Alfarano, Chiara, Timotin, Andrei, Calise, Denis, Anesia, Rodica, Drougard, Anne, Knauf, Claude, Lagente, Christine, Roncalli, Jerome, Desmoulin, Franck, Tronchere, Helene, Valet, Philippe, Parini, Angelo, Kunduzova, Oksana
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 14 14/19 14/28 38 38/77 59 631/443/592/75 64 64/60 692/699/75/230 82 Adipocytes - metabolism Aged Animals Beta blockers Cardiomyocytes Cardiotonic Agents - metabolism Cell fate Cells, Cultured Confocal microscopy Cross-Sectional Studies Diet, High-Fat - adverse effects Disease Models, Animal Etiology Female Forkhead Transcription Factors - metabolism FOXO3 protein Heart diseases Heart Failure High fat diet Humanities and Social Sciences Humans Intercellular Signaling Peptides and Proteins - blood Intercellular Signaling Peptides and Proteins - metabolism Ischemia Male Mice Mice, Inbred C57BL Middle Aged multidisciplinary Myocardial Reperfusion Injury - metabolism Myocardium - metabolism Myocytes, Cardiac - metabolism Nuclear transport Obesity Obesity - metabolism Phosphatidylinositol 3-Kinases - metabolism Prospective Studies Rats Reperfusion Rodents Science Translocation Ventricle Ventricular Function, Left - physiology
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