Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity

The increasing incidence of obesity accentuates the importance of identifying mechanisms and optimal therapeutic strategies for patients with heart failure (HF) in relation to obesity status. Here, we investigated the association between plasma level of apelin, an adipocyte-derived factor and clinicopathological features of obese and non-obese patients with HF. We further explored potential regulatory mechanisms of cardiac cell fate responses in conditions combining myocardial injury and obesity. In a prospective, cross-sectional study involving patients with HF we show that obese patients (BMI ≥30 kg/m 2 ) have higher left ventricular ejection fraction (LVEF) and greater levels of plasma apelin (p