Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury

Few preclinical studies have assessed the long-term neuropathology and behavioral deficits after sustaining blast-induced neurotrauma (BINT). Previous studies have shown extensive astrogliosis and cell death at acute stages (

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Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2015-11, Vol.5 (1), p.15075-15075, Article 15075
Hauptverfasser:	Sajja, Venkata Siva Sai Sujith, Hubbard, W. Brad, Hall, Christina S., Ghoddoussi, Farhad, Galloway, Matthew P., VandeVord, Pamela J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/63 140/131 59 631/378/1595/1554 631/378/1934 631/378/371 alpha-Synuclein - metabolism Amygdala Amygdala - metabolism Amygdala - pathology Animals Apoptosis Apoptosis - physiology Avoidance behavior Behavior Brain Injuries - metabolism Brain Injuries - pathology Caspase Caspase 3 - metabolism Caspase-3 Cell death Complications Creatine Disease Models, Animal Glial fibrillary acidic protein Gliosis Gliosis - metabolism Gliosis - pathology Glycine Hippocampus - metabolism Hippocampus - pathology Humanities and Social Sciences Inositol Long-term effects Male Memory, Short-Term - physiology Microglia multidisciplinary Neurodegeneration Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurons - metabolism Neurons - pathology Nucleus accumbens Nucleus Accumbens - metabolism Nucleus Accumbens - pathology Prefrontal cortex Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Rats Rats, Sprague-Dawley Science Short term memory Synuclein Tau protein Temporal lobe Traumatic brain injury
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Beschreibung
Zusammenfassung:	Few preclinical studies have assessed the long-term neuropathology and behavioral deficits after sustaining blast-induced neurotrauma (BINT). Previous studies have shown extensive astrogliosis and cell death at acute stages (
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep15075