Prenatal exposure to ethanol stimulates hypothalamic CCR2 chemokine receptor system: Possible relation to increased density of orexigenic peptide neurons and ethanol drinking in adolescent offspring

Highlights • Maternal drinking of low ethanol increases ethanol drinking in adolescent offspring. • Prenatal ethanol increases MCH in lateral hypothalamus of preadolescent offspring. • Prenatal ethanol increases CCR2 in lateral hypothalamus of preadolescent offspring. • Prenatal ethanol increases pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-12, Vol.310, p.163-175
Hauptverfasser:	Chang, G.-Q, Karatayev, O, Leibowitz, S.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Alcohol Drinking - physiopathology Animals Animals, Newborn CCL2 CCR2 Central Nervous System Depressants - toxicity Chemokine CCL2 - metabolism Ethanol - toxicity Female Gene Expression Regulation, Developmental - drug effects Humans Hypothalamic Hormones - genetics Hypothalamic Hormones - metabolism Hypothalamus - drug effects Hypothalamus - metabolism Infant, Newborn lateral hypothalamus Male melanin-concentrating hormone Melanins - genetics Melanins - metabolism neurogenesis Neurology Neurons - drug effects Neurons - metabolism Phosphopyruvate Hydratase - metabolism Pituitary Hormones - genetics Pituitary Hormones - metabolism Pregnancy prenatal ethanol Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - pathology Rats Rats, Sprague-Dawley Receptors, CCR2 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Maternal drinking of low ethanol increases ethanol drinking in adolescent offspring. • Prenatal ethanol increases MCH in lateral hypothalamus of preadolescent offspring. • Prenatal ethanol increases CCR2 in lateral hypothalamus of preadolescent offspring. • Prenatal ethanol increases proliferation of CCR2 and MCH co-expressing neurons.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.09.020