Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture

Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture

Highlights • Substance P signaling contributed to spinal glial activation and nociceptive sensitization. • C-fiber afferent signaling induced spinal glial activation and hypersensitivity. • Neuroglial activation contributed to the maintenance of chronic post fracture hypersensitivity.

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Veröffentlicht in:Neuroscience 2015-12, Vol.310, p.73-90
Hauptverfasser: Li, W.-W, Guo, T.-Z, Shi, X, Sun, Y, Wei, T, Clark, D.J, Kingery, W.S
Format: Artikel
Sprache:eng
Schlagworte:
2-Aminoadipic Acid - pharmacology
Animals
Anti-Inflammatory Agents - therapeutic use
astrocytes
complex regional pain syndrome
Complex Regional Pain Syndromes - etiology
Complex Regional Pain Syndromes - pathology
Disease Models, Animal
Edema - drug therapy
Edema - etiology
Excitatory Amino Acid Antagonists - pharmacology
fracture
Hyperalgesia - physiopathology
Male
microglia
Minocycline - therapeutic use
Neuroglia - metabolism
Neuroglia - pathology
Neurology
Nociception - physiology
Pain Measurement
Pain Threshold - physiology
Rats
Rats, Sprague-Dawley
Signal Transduction - drug effects
Signal Transduction - physiology
Spinal Cord - pathology
substance P
Substance P - metabolism
Tibial Fractures - complications
Time Factors
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Beschreibung
Zusammenfassung:Highlights • Substance P signaling contributed to spinal glial activation and nociceptive sensitization. • C-fiber afferent signaling induced spinal glial activation and hypersensitivity. • Neuroglial activation contributed to the maintenance of chronic post fracture hypersensitivity.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.09.036