Phoenixin: A candidate pruritogen in the mouse

Highlights • Phoenixin (PNX), a novel peptide of 14 amino acids, is detected in the mouse spinal cord. • PNX is expressed in DRGs with axons projecting to the dorsal horn and peripherally to the skin. • PNX upon subcutaneous injection to the nape of the neck of mice provokes scratching behavior. • P...

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Veröffentlicht in:	Neuroscience 2015-12, Vol.310, p.541-548
Hauptverfasser:	Cowan, A, Lyu, R.-M, Chen, Y.-H, Dun, S.L, Chang, J.-K, Dun, N.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Animals Behavior, Animal - drug effects Cervical Cord - metabolism dorsal root ganglion Ganglia, Spinal - metabolism itch kappa opioid receptor Male Mice nalfurafine Neck - innervation Neurology Peptides - chemistry Peptides - metabolism Peptides - pharmacology Peptides - physiology primary afferent neuron pruritogen Pruritus - chemically induced Skin - metabolism Spinal Cord - metabolism
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Zusammenfassung:	Highlights • Phoenixin (PNX), a novel peptide of 14 amino acids, is detected in the mouse spinal cord. • PNX is expressed in DRGs with axons projecting to the dorsal horn and peripherally to the skin. • PNX upon subcutaneous injection to the nape of the neck of mice provokes scratching behavior. • PNX-induced scratching is attenuated by nalfurafine, the kappa opioid receptor agonist. • PNX is one of the endogenous signaling molecules involved in itch transmission in the mouse.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.09.055