Serum Oxidative Stress Markers and Genotoxic Profile Induced by Chemotherapy in Patients with Breast Cancer: A Pilot Study

The aim of this study was to evaluate the oxidative parameters of erythrocytes and genotoxicity in leukocytes of patients with breast cancer. Oxidative parameters were detected by spectrophotometry and genotoxic damage by single cell gel electrophoresis. Twenty-eight women with breast cancer were mo...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2015-01, Vol.2015 (2015), p.1-11
Hauptverfasser:	Cavalcante, Ana Amélia de Carvalho Melo, de Freitas, Rivelilson Mendes, Ferreira, Paulo Michel Pinheiro, Machado, Kátia da Conceição, Sobral, André Luiz Pinho, Carvalho, Simone da Costa e Silva, Silva, Laís Iasmin Soares da, Paz, Marcia Fernanda Correia Jardim, Júnior, Antonio Luiz Gomes, Satyal, Prabodh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anthracyclines Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antioxidants Biomarkers, Tumor - blood Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer patients Cancer therapies Care and treatment Case-Control Studies Chemotherapy Clinical Study Colleges & universities Comet Assay Cyclophosphamide Cyclophosphamide - pharmacology Cyclophosphamide - therapeutic use Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects Doxorubicin - pharmacology Doxorubicin - therapeutic use Erythrocytes - cytology Erythrocytes - drug effects Erythrocytes - metabolism Female Free radicals Glutathione - metabolism Glutathione Peroxidase - metabolism Health aspects Humans Laboratories Leukocytes - cytology Leukocytes - drug effects Leukocytes - metabolism Lifestyles Middle Aged Oncology, Experimental Oxidative stress Oxidative Stress - drug effects Pharmaceutical sciences Pharmaceuticals Pilot Projects Spectrophotometry Superoxide Superoxide Dismutase - metabolism Women
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Zusammenfassung:	The aim of this study was to evaluate the oxidative parameters of erythrocytes and genotoxicity in leukocytes of patients with breast cancer. Oxidative parameters were detected by spectrophotometry and genotoxic damage by single cell gel electrophoresis. Twenty-eight women with breast cancer were monitored before chemotherapy and after the second and fourth cycles of therapy with cyclophosphamide and doxorubicin. After the fourth cycle, increases (P
ISSN:	1942-0900 1942-0994
DOI:	10.1155/2015/212964