Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis

Highlights • Eye muscles are spared in muscular dystrophy models in the absence of dystrophin and utrophin. • Pax7- and MyoD-positive cells were retained and were similar to age-matched wild type controls. • Thus, utrophin is not involved in extraocular muscle sparing in these genotypes.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuromuscular disorders : NMD 2015-11, Vol.25 (11), p.873-887
Hauptverfasser:	McDonald, Abby A, Hebert, Sadie L, McLoon, Linda K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aging - pathology Animals Collagen - metabolism Extraocular muscle Fibrosis Image Processing, Computer-Assisted Immunohistochemistry Mice, Inbred mdx Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular dystrophy MyoD MyoD Protein - metabolism Neurology Oculomotor Muscles - growth & development Oculomotor Muscles - metabolism Oculomotor Muscles - pathology Organ Size Pax7 PAX7 Transcription Factor - metabolism Satellite cell Utrophin Utrophin - genetics Utrophin - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Eye muscles are spared in muscular dystrophy models in the absence of dystrophin and utrophin. • Pax7- and MyoD-positive cells were retained and were similar to age-matched wild type controls. • Thus, utrophin is not involved in extraocular muscle sparing in these genotypes.
ISSN:	0960-8966 1873-2364
DOI:	10.1016/j.nmd.2015.09.001