Cell of origin of transformed follicular lymphoma

Cell of origin of transformed follicular lymphoma

Follicular lymphoma (FL) is an indolent disease but transforms in 2% to 3% of patients per year into aggressive, large cell lymphoma, a critical event in the course of the disease associated with increased lymphoma-related mortality. Early transformation cannot be accurately predicted at the time of...

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Veröffentlicht in:Blood 2015-10, Vol.126 (18), p.2118-2127
Hauptverfasser: Kridel, Robert, Mottok, Anja, Farinha, Pedro, Ben-Neriah, Susana, Ennishi, Daisuke, Zheng, Yvonne, Chavez, Elizabeth A., Shulha, Hennady P., Tan, King, Chan, Fong Chun, Boyle, Merrill, Meissner, Barbara, Telenius, Adele, Sehn, Laurie H., Marra, Marco A., Shah, Sohrab P., Steidl, Christian, Connors, Joseph M., Scott, David W., Gascoyne, Randy D.
Format: Artikel
Sprache:eng
Schlagworte:
B-Lymphocytes - metabolism
B-Lymphocytes - pathology
CARD Signaling Adaptor Proteins - genetics
CD79 Antigens - genetics
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - pathology
Female
Germinal Center - metabolism
Germinal Center - pathology
Guanylate Cyclase - genetics
Humans
Lymphoid Neoplasia
Lymphoma, Follicular - genetics
Lymphoma, Follicular - pathology
Male
Middle Aged
Mutation
Myeloid Differentiation Factor 88 - genetics
Proto-Oncogene Proteins c-bcl-2 - genetics
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Beschreibung
Zusammenfassung:Follicular lymphoma (FL) is an indolent disease but transforms in 2% to 3% of patients per year into aggressive, large cell lymphoma, a critical event in the course of the disease associated with increased lymphoma-related mortality. Early transformation cannot be accurately predicted at the time of FL diagnosis and the biology of transformed FL (TFL) is poorly understood. Here, we assembled a cohort of 126 diagnostic FL specimens including 40 patients experiencing transformation (
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2015-06-649905