Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons

Highlights • CB1, trkA, and TRPV1 are co-localized in a subpopulation of adult mouse afferent neurons. • NGF increased the number of neurons that responded to capsaicin. • CB1 agonist ACEA (10 nM) inhibited the NGF-induced responses. • ACEA inhibited NGF-induced phosphorylation of AKT. • Blocking PI...

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Veröffentlicht in:	Neuroscience 2014-09, Vol.277, p.679-689
Hauptverfasser:	Wang, Z.-Y, McDowell, T, Wang, P, Alvarez, R, Gomez, T, Bjorling, D.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - pharmacology Calcium - metabolism cannabinoid receptor 1 Cannabinoid Receptor Agonists - pharmacology capsaicin Capsaicin - pharmacology Cells, Cultured Enzyme Inhibitors - pharmacology Ganglia, Spinal - drug effects Ganglia, Spinal - physiology Intracellular Space - drug effects Intracellular Space - metabolism Male Mice, Inbred C57BL nerve growth factor Nerve Growth Factor - metabolism Neurology Neurons, Afferent - drug effects Neurons, Afferent - physiology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects phosphorylation of AKT Proto-Oncogene Proteins c-akt - metabolism Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - metabolism Receptor, trkA - metabolism sensitization Sensory System Agents - pharmacology transient receptor potential vanilloid 1 TRPV Cation Channels - metabolism
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Zusammenfassung:	Highlights • CB1, trkA, and TRPV1 are co-localized in a subpopulation of adult mouse afferent neurons. • NGF increased the number of neurons that responded to capsaicin. • CB1 agonist ACEA (10 nM) inhibited the NGF-induced responses. • ACEA inhibited NGF-induced phosphorylation of AKT. • Blocking PI3 kinase activity attenuated the NGF-induced responses.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.07.041