Safety and efficacy of ketamine infusion in late onset depression, and conversion to treatment response

Ratings of mood (Hamilton rating scale for depression [HAMD])[3] and side effects (Clinician Administered Dissociative States Scale)[4] were undertaken on morning of the infusion, and 1, 2, and 4 h following infusions, and on in between days of the infusion [labelled as postinfusion days in Table 1]. From the first episode 3 years ago, subsequent episodes became more difficult to treat; amisulpride worked effectively as augmentation agent in the previous episodes when co-administered with a selective serotonin reuptake inhibitor and serotonin and norepinephrine reuptake inhibitors, respectively, ketamine was well tolerated with minor and transient side effects; and the remission induced by ketamine infusions was maintained on the same antidepressant agomelatine.