GH deficiency status combined with GH receptor polymorphism affects response to GH in children

Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. The associations between GHRd3 and growth response to r-hGH over 3 years in rela...

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Veröffentlicht in:	European journal of endocrinology 2015-12, Vol.173 (6), p.777-789
Hauptverfasser:	Valsesia, Armand, Chatelain, Pierre, Stevens, Adam, Peterkova, Valentina A, Belgorosky, Alicia, Maghnie, Mohamad, Antoniazzi, Franco, Koledova, Ekaterina, Wojcik, Jerome, Farmer, Pierre, Destenaves, Benoit, Clayton, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Glucose - metabolism Body Height Child Cholesterol, HDL - metabolism Cholesterol, LDL - metabolism Clinical Study Dwarfism, Pituitary - drug therapy Dwarfism, Pituitary - genetics Dwarfism, Pituitary - metabolism Exons Female Gene Expression Profiling Growth Disorders - drug therapy Growth Disorders - genetics Growth Disorders - metabolism Human Growth Hormone - deficiency Human Growth Hormone - therapeutic use Humans Insulin - metabolism Insulin-Like Growth Factor Binding Protein 3 - metabolism Insulin-Like Growth Factor I - metabolism Longitudinal Studies Male Polymorphism, Genetic Prospective Studies Receptors, Somatotropin - genetics Recombinant Proteins Severity of Illness Index Thyrotropin - metabolism Thyroxine - metabolism Treatment Outcome Triglycerides - metabolism
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Zusammenfassung:	Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. The associations between GHRd3 and growth response to r-hGH over 3 years in relation to severity of GH deficiency (GHD) were investigated in patients from 14 countries. Treatment-naïve pre-pubertal children with GHD were enrolled from the PREDICT studies (NCT00256126 and NCT00699855), categorized by peak GH level (peak GH) during provocation test: ≤4 μg/l (severe GHD; n=45) and >4 to
ISSN:	0804-4643 1479-683X
DOI:	10.1530/EJE-15-0474